Effects of gustatory stimulants of salivary secretion on salivary pH and flow in patients with Sjögren's syndrome: a randomized controlled trial.

Autor: da Silva Marques DN; Oral Biology and Biochemistry Group, Biomedical and Oral Sciences Research Unit (FCT Unit 4062), University of Lisbon School of Dental Medicine, Portugal. duartemd@yahoo.co.uk, da Mata AD, Patto JM, Barcelos FA, de Almeida Rato Amaral JP, de Oliveira MC, Ferreira CG
Jazyk: angličtina
Zdroj: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2011 Nov; Vol. 40 (10), pp. 785-92. Date of Electronic Publication: 2011 Apr 11.
DOI: 10.1111/j.1600-0714.2011.01038.x
Abstrakt: Objectives: To compare salivary pH changes and stimulation efficacy of two different gustatory stimulants of salivary secretion (GSSS) in patients with primary Sjögren syndrome.
Setting: Portuguese Institute for Rheumatological Diseases.
Design: Double-blind randomized controlled trial.
Subjects: Eighty patients were randomized to two intervention groups. Sample size was calculated using an alpha error of 0.05 and a beta of 0.20.
Materials and Methods: Participants were randomly assigned to receive a new GSSS containing a weaker malic acid, fluoride and xylitol or a traditionally citric acid-based one. Saliva collection was obtained by established methods at different times. The salivary pH of the samples was determined with a pH meter and a microelectrode.
Main Outcome Measures: Salivary pH variations and counts of subjects with pH below 4.5 for over 1 min and stimulated salivary flow were the main outcome measures.
Results: Both GSSS significantly stimulated salivary output without significant differences between the two groups. The new gustatory stimulant of salivary secretion presented an absolute risk reduction of 52.78% [33.42-72.13 (95% CI)] when compared with the traditional one.
Conclusions: In Xerostomic Primary Sjögren syndrome patients, gustatory stimulants of salivary secretion based on acid mail only with fluoride and xylitol present similar salivary stimulation capacity when compared to citric acid-based ones, besides significantly reducing the number of salivary pH drops below 4.5. This could be related to a diminished risk for dental erosion and should be confirmed with further studies.
(© 2011 John Wiley & Sons A/S.)
Databáze: MEDLINE
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