RASSF1A suppresses the activated K-Ras-induced oxidative DNA damage.

Autor: Park SH; Laboratory of Molecular Cell Biology, Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705, Republic of Korea., Kim JJ, Chung JS, Lee SR, Lee GY, Kim HJ, Yoo YD
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2011 Apr 29; Vol. 408 (1), pp. 149-53. Date of Electronic Publication: 2011 Apr 05.
DOI: 10.1016/j.bbrc.2011.03.139
Abstrakt: The mutant K-Ras elevates intracellular reactive oxygen species (ROS) levels and leads to oxidative DNA damage, resulting in malignant cell transformation. Ras association domain family 1 isoform A (RASSF1A) is known to play a role as a Ras effector. However, the suppressive effect of RASSF1A on K-RasV12-induced ROS increase and DNA damage has not been identified. Here, we show that RASSF1A blocks K-RasV12-triggered ROS production. RASSF1A expression also inhibits oxidative DNA damage and chromosomal damage. From the results obtained in this study, we suggest that RASSF1A regulates the cellular ROS levels enhanced by the Ras signaling pathway, and that it may function as a tumor suppressor by suppressing DNA damage caused by activated Ras.
(Copyright © 2011 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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