| Autor: |
Wenig BL; Department of Otolaryngology-Head and Neck Surgery, University of Illinois College of Medicine, Chicago., Kurtzman DM, Grossweiner LI, Mafee MF, Harris DM, Lobraico RV, Prycz RA, Appelbaum EL |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of otolaryngology--head & neck surgery [Arch Otolaryngol Head Neck Surg] 1990 Nov; Vol. 116 (11), pp. 1267-70. |
| DOI: |
10.1001/archotol.1990.01870110039003 |
| Abstrakt: |
Photodynamic therapy is an experimental modality for tumor treatment based on the combined action of the tumor-localizing agent, ie, hematoporphyrin derivative, and red light. From 1985 through 1989, 26 patients were treated using hematoporphyrin-derived drugs and 630-nm light delivered by a tunable dye laser. All patients had biopsy-proved squamous cell carcinoma of the head and neck, and they had either failed the traditional treatment modalities or refused conventional therapies. Histological complete responses were achieved in 20 (77%) of 26 patients and partial responses in 5 (19%) of 26 patients for periods up to 48 months. Only minimal toxic reaction was noted in the group. As a guide to treatment planning for a patient group with large tumors, we used an optical dosimetry model based on tissue optics. The rate of complete responses to this treatment was 8 (73%) of 11. Our data indicate that photodynamic therapy is capable of inducing significant clinical and histological responses in the majority of those treated, and in some patients a prolonged response is produced. In certain select head and neck malignancies, photodynamic therapy has an important role as a treatment modality. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
