An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant.

Autor: Guillem VM; Servicio de Hematología y Oncología Médica, Hospital Clínico Universitario de Valencia, Fundación Investigación Hospital Clinico de Valencia, Valencia, Spain., Arbona C, Hernández-Boluda JC, Terol MJ, Goterris R, Solano C, Tormo M
Jazyk: angličtina
Zdroj: Leukemia & lymphoma [Leuk Lymphoma] 2011 Jul; Vol. 52 (7), pp. 1249-54. Date of Electronic Publication: 2011 Apr 04.
DOI: 10.3109/10428194.2011.564694
Abstrakt: High-dose chemotherapy supported by autologous stem cell transplant (ASCT) remains the treatment of choice for patients with lymphoma failing first-line chemotherapy. Recent evidence suggests a relationship between the genetic variations in genes involved in DNA repair and the outcome of patients with a number of malignancies. In this work, we retrospectively evaluated the influence of an XRCC1 polymorphism (rs25487) on the treatment results in a series of 73 patients with lymphoma subjected to ASCT. The factors correlated to overall survival were the disease status at transplant and XRCC1 genotype. Carriers of a mutant A allele had a two-fold higher risk of death than those with the wild-type genotype. In addition, patients harboring one or two copies of the A allele (GA/AA) were 4.5-fold more likely to develop therapy-related acute myeloid (t-AML). Thus, the cumulative probability of t-AML at 10 years was 37 ± 13% in patients with the mutant A allele as compared to 8.5 ± 6% in the remaining cases (p = 0.04). Our findings suggest that genetic variation in the DNA repair gene XRCC1 may play a role in the results of transplant in patients with lymphoma.
Databáze: MEDLINE
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