| Autor: |
Holtzman JL; Department of Medicine and Pharmacology, Veterans Administration Medical Center, Minneapolis, MN 55417., Abrams A, Cutler R, Hamilton B, Kirkendall WM, Neri G, Stein GH, Matthews KP |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 1990 Nov; Vol. 48 (5), pp. 590-7. |
| DOI: |
10.1038/clpt.1990.196 |
| Abstrakt: |
After 8 weeks of isradipine, a twice-a-day dihydropyridine calcium channel blocker, 49% of elderly patients showed a complete response (sitting diastolic blood pressure less than or equal to 85 mm Hg) and 36% showed a partial response (sitting diastolic blood pressure decrease greater than or equal to 10 mm Hg) for an 85% total response rate. Hydrochlorothiazide gave a complete response in 36% of the patients and a partial response in 33%, for a 69% total response rate (p less than 0.0046). Because elderly subjects have reduced clearance for many drugs, we determined how those who responded to twice-a-day administration would respond to once-a-day administration. After 4 weeks of isradipine administered once a day, 54% of the patients showed a complete or partial response, whereas 38% of the patients who were changed to placebo showed a response. In contrast, 82% of patients receiving hydrochlorothiazide once a day showed a response, whereas 60% of patients who were changed to placebo showed a response. These data indicate that the standard formulation of isradipine was not effective when administered once a day. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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