Interleukin-4 and interferon- γ levels in Epstein-Barr virus-associated infectious mononucleosis and nasopharyngeal carcinoma.
| Autor: | Budiani DR; Lecturer, Immunology Unit, Department of Pathology, School of Medicine, Sebelas Maret University, Surakarta, Indonesia., Haryana SM, Sosroseno W |
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| Jazyk: | angličtina |
| Zdroj: | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences [J Res Med Sci] 2011 Jan; Vol. 16 (1), pp. 94-7. |
| Abstrakt: | Background: Cytokines have been suggested to participate in the pathogenesis of infectious mononucleosis (IM) and nasopharyngeal carcinoma (NPC). Methods: Serum levels and gene expression of interleukin-4 (IL-4) and interferon-γ (IFN-γ) were assessed by immunologic and PCR assays, respectively in patients with Epstein-Barr virus (EBV)-associated IM and NPC and EBV nega-tive controls. Results: The serum levels of IFN- γ were elevated, but those of IL-4 were decreased in IM and NPC patients as compared with those of the control group (p < 0.05). Conclusions: These results suggest that serum levels of IFN-γ may be predominant over those of IL-4 during the course of IM and NPC. |
| Databáze: | MEDLINE |
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