Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice.
| Autor: | Andres AM; Department of Biology, BioScience Center, San Diego State University, San Diego, CA 92182, USA., Ratliff EP, Sachithanantham S, Hui ST |
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| Jazyk: | angličtina |
| Zdroj: | FEBS letters [FEBS Lett] 2011 Apr 20; Vol. 585 (8), pp. 1223-30. Date of Electronic Publication: 2011 Mar 23. |
| DOI: | 10.1016/j.febslet.2011.03.042 |
| Abstrakt: | Thioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate-activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip. (Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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