| Autor: |
Barabash RD, Skobelkin OK, Petukhov MI, Normanskiĭ VE, Riazhskiĭ GG, Mironova MI, Andreeva KP, Kolobanov AS |
| Jazyk: |
ruština |
| Zdroj: |
Farmakologiia i toksikologiia [Farmakol Toksikol] 1990 May-Jun; Vol. 53 (3), pp. 24-6. |
| Abstrakt: |
The pharmacokinetics of fluorescein, hematoporphyrin and a derivative of hematoporphyrin was studied microspectrofluorometrically on rats with transplanted carcinosarcoma. It was shown that in the rats in contrast to intact animals the tissue concentration of fluorescein exhibits a general tendency towards an increase, that of hematoporphyrin towards a decrease and that of hematoporphyrin derivative towards an increase in all parenchymatous organs and a decrease in the skin and mucosae of the hollow organs. At the equally short period of the maximal accumulation of luminophores, the tumour tissue differs from the normal one by a pronounced delay of excretion only of hematoporphyrin derivative. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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