Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S.

Autor: Roos KL; Department of Neurology, Indiana University School of Medicine, Indianapolis., Pascuzzi RM, Kuharik MA, Shapiro AD, Manco-Johnson MJ
Jazyk: angličtina
Zdroj: Obstetrics and gynecology [Obstet Gynecol] 1990 Sep; Vol. 76 (3 Pt 2), pp. 492-4.
Abstrakt: Development of intracranial dural sinus thrombosis in the postpartum period has been attributed to the hypercoagulable state of pregnancy. With increasing recognition of the role of the vitamin K-dependent proteins, protein C and protein S, in intracranial venous and arterial thrombotic events, our understanding of the cause of thrombotic events has improved. We report a patient who developed a superior sagittal sinus thrombosis in the second week postpartum, associated with a dysfunctional protein C and a decreased free protein S concentration.
Databáze: MEDLINE