Four new carvotanacetone derivatives from Sphaeranthus ukambensis, inhibitors of the ubiquitin-proteasome pathway.
Autor: | Pouny I; Unité Mixte de Service 2597, Centre National de la Recherche Scientifique (CNRS)-Pierre Fabre, Institut des Sciences et Technologies du Médicament de Toulouse, Toulouse, France. isabelle.pouny@pierre-fabre.com, Vispé S, Marcourt L, Long C, Vandenberghe I, Aussagues Y, Raux R, Chalo Mutiso PB, Massiot G, Sautel F |
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Jazyk: | angličtina |
Zdroj: | Planta medica [Planta Med] 2011 Sep; Vol. 77 (14), pp. 1605-9. Date of Electronic Publication: 2011 Mar 21. |
DOI: | 10.1055/s-0030-1270935 |
Abstrakt: | Six carvotanacetone derivatives (1- 6), amongst which four new compounds (1- 4), were isolated from the aerial parts of Sphaeranthus ukambensis Vatke & O. Hoffm. The structures of the molecules were elucidated by complementary spectroscopic methods, and their biological properties were investigated using human DLD-1 colon cancer cells engineered to stably express a 4 ubiquitin-luciferase (4 Ub-Luc) reporter protein. Five of the isolated carvotanacetone derivatives (2- 6) were found to inhibit the proliferation of the colon cancer cells and interfere with the ubiquitin-proteasome pathway, with potencies in a micromolar range. (© Georg Thieme Verlag KG Stuttgart · New York.) |
Databáze: | MEDLINE |
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