Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines.
| Autor: | Garcia P; UPMC, Université Paris 06, IPCM 7201, 4 Place Jussieu, 75252 Paris Cedex 05, France., Evanno Y, George P, Sevrin M, Ricci G, Malacria M, Aubert C, Gandon V |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2011 Apr 15; Vol. 13 (8), pp. 2030-3. Date of Electronic Publication: 2011 Mar 17. |
| DOI: | 10.1021/ol200417p |
| Abstrakt: | Bimolecular cobalt-catalyzed [2 + 2 + 2] cycloadditions between yne-ynamides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts groups are efficiently deprotected in an orthogonal fashion. (© 2011 American Chemical Society) |
| Databáze: | MEDLINE |
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