| Autor: |
Chowdhary RK; Department of Biological Sciences, University of Salford, UK., Cundall RB, Morgan CG |
| Jazyk: |
angličtina |
| Zdroj: |
Photochemistry and photobiology [Photochem Photobiol] 1990 Apr; Vol. 51 (4), pp. 395-9. |
| DOI: |
10.1111/j.1751-1097.1990.tb01730.x |
| Abstrakt: |
The influence of fluorocarbon emulsions on the efficiency of photosensitized oxidation of histidine in solution has been studied, using haematoporphyrin and dihaematoporphyrin derivatives as sensitisers. It is shown that the fluorocarbon emulsions at low concentrations efficiently disaggregate porphyrins, and thereby enhance photosensitised oxidation. The high solubility of oxygen in fluorocarbon emulsions maintains solution oxygen tension, optimising photooxidative damage. It is suggested that fluorocarbon emulsions might find a role in photodynamic therapy, both as carriers for sensitising dyes, and also to maintain tissue oxygenation in hypoxic regions of solid tumours. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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