Stress-dependent impairment of passive-avoidance memory by propranolol or naloxone.

Autor: Schneider AM; Department of Psychology, Swarthmore College, Swarthmore, PA 19081, United States. ASchnei1@Swarthmore.edu, Simson PE, Atapattu RK, Kirby LG
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2011 Jun; Vol. 98 (4), pp. 539-43. Date of Electronic Publication: 2011 Mar 17.
DOI: 10.1016/j.pbb.2011.03.005
Abstrakt: Previous work has shown that the effect of opioid-receptor blockade on memory modulation is critically dependent upon the intensity of stress. The current study determined the effect of adrenergic-receptor blockade on memory modulation under varied levels of stress and then compared the effect of adrenergic-receptor blockade under intense stress to that of a) opioid-receptor blockade and b) concurrent opioid- and adrenergic-receptor blockade. In the first experiment, the β-adrenergic-receptor blocker propranolol impaired retention in the passive-avoidance procedure when administered immediately after exposure to intense stress (passive-avoidance training followed by swim stress) but not mild stress (passive-avoidance training alone). In the second experiment, while separate administration of either propranolol or the opioid-receptor blocker naloxone immediately after exposure to intense stress impaired retention, the combined administration of propranolol and naloxone failed to do so. These findings demonstrate that the effect of β-adrenergic-receptor blockade or opioid-receptor blockade on memory modulation in the passive-avoidance procedure is dependent upon the intensity of stress, and suggest that concurrent inactivation of endogenous adrenergic- and opioid-based memory modulation systems under stressful conditions is protective of memory.
(Copyright © 2011 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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