Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius.

Autor: Bungihan ME; University of Santo Tomas, España, Manila, Philippines., Tan MA, Kitajima M, Kogure N, Franzblau SG, Dela Cruz TE, Takayama H, Nonato MG
Jazyk: angličtina
Zdroj: Journal of natural medicines [J Nat Med] 2011 Jul; Vol. 65 (3-4), pp. 606-9. Date of Electronic Publication: 2011 Mar 11.
DOI: 10.1007/s11418-011-0518-x
Abstrakt: Two new benzopyranones, diaportheone A (1) and B (2), were obtained via bioassay-guided isolation of the secondary metabolites from the endophytic fungus Diaporthe sp. P133 isolated from Pandanus amaryllifolius leaves. Their structures were determined from spectral analysis including mass spectrometry, 1D and 2D nuclear magnetic resonance. Both 1 and 2 inhibited the growth of the virulent strain of Mycobacterium tuberculosis H(37)Rv with minimum inhibitory concentrations of 100.9 and 3.5 μM, respectively.
Databáze: MEDLINE