| Autor: |
Montgomery SB; Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel-Servet, Geneva 1211, Switzerland. Stephen.Montgomery@unige.ch, Dermitzakis ET |
| Jazyk: |
angličtina |
| Zdroj: |
Nature reviews. Genetics [Nat Rev Genet] 2011 Apr; Vol. 12 (4), pp. 277-82. Date of Electronic Publication: 2011 Mar 09. |
| DOI: |
10.1038/nrg2969 |
| Abstrakt: |
Approaches that combine expression quantitative trait loci (eQTLs) and genome-wide association (GWA) studies are offering new functional information about the aetiology of complex human traits and diseases. Improved study designs--which take into account technological advances in resolving the transcriptome, cell history and state, population of origin and diverse endophenotypes--are providing insights into the architecture of disease and the landscape of gene regulation in humans. Furthermore, these advances are helping to establish links between cellular effects and organismal traits. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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