Experimental validation of a new integrated simulated moving bed process for the production of single enantiomers.
| Autor: | Palacios JG; Max-Planck-Institut für Dynamik komplexer technischer Systeme, D-39106 Magdeburg, Germany., Kramer B, Kienle A, Kaspereit M |
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| Jazyk: | angličtina |
| Zdroj: | Journal of chromatography. A [J Chromatogr A] 2011 Apr 22; Vol. 1218 (16), pp. 2232-9. Date of Electronic Publication: 2011 Feb 17. |
| DOI: | 10.1016/j.chroma.2011.02.021 |
| Abstrakt: | A new integrated 3-zone simulated moving bed (SMB) concept with internal racemization reaction was suggested recently for the production of single enantiomers from racemic mixtures [1,2]. The process utilizes an internal gradient to trigger the racemization within a single zone. It can deliver the pure enantiomer and outperforms conventional technologies. In this contribution, the concept is validated experimentally for the separation of a model system compound. The results demonstrate that the new concept is capable of producing a single enantiomer with purity, yield and conversion of 100%. (Copyright © 2011 Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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