| Autor: |
Vieira-Júnior GM; Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, C.P. 14801-970, Araraquara, SP, Brazil., Dutra LA, Ferreira PM, de Moraes MO, Costa Lotufo LV, Pessoa Cdo Ó, Torres RB, Boralle N, Bolzani Vda S, Cavalheiro AJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2011 Apr 25; Vol. 74 (4), pp. 776-81. Date of Electronic Publication: 2011 Mar 07. |
| DOI: |
10.1021/np100840w |
| Abstrakt: |
Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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