[Association between expression of lectin type receptors by natural killers and intensity of liver fibrosis during chronic hepatitis C].

Autor:	Malova ES, Balmasova IP, Iuschuk ND, Shmeleva EV, Eremina OF
Jazyk:	ruština
Zdroj:	Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2010 Nov-Dec (6), pp. 48-52.
Abstrakt:	Aim: To study functional activity of natural killers on different stages of fibrosis during chronic hepatitis C. Materials and Methods: Functional activity of CD3-/CD56+/CD16+ lymphocytes measured as expression of natural killers receptors (NKR) and natural cytotoxicity receptors (NCR) was assessed by flow cytometry. Results: At stage I of fibrosis, decrease of number of CD3-/CD56+/NKG2D+ cells was observed, whereas at precirrhotic stage III--sharp decrease of CD3-/CD56+/CD94+ and CD3-/ CD56+/NKG2D+ populations, and at cirrhotic stage--decrease of number of CD3-/CD56+/ NKG2D+ cells and increase of cytolytic activity of natural killers carrying CD107a marker compared to precirrhotic stage. Conclusion: Obtained data demonstrate that natural killers during chronic hepatitis C receive regulatory signals mainly through lectin type receptors (CD94 and NKG2D).
Databáze:	MEDLINE
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