Macrophages and neutrophils cooperate in immune responses to Leishmania infection.

Autor: Filardy AA; Centro de Ciências da Saúde, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), 21949-900 Rio de Janeiro, RJ, Brazil. gdosreis@biof.ufrj.br, Pires DR, DosReis GA
Jazyk: angličtina
Zdroj: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2011 Jun; Vol. 68 (11), pp. 1863-70. Date of Electronic Publication: 2011 Mar 03.
DOI: 10.1007/s00018-011-0653-2
Abstrakt: Neutrophils and macrophages are phagocytic cells that cooperate during inflammation and tissue repair. Neutrophils undergo apoptosis and are engulfed by macrophages. Engulfment modulates macrophage activation and microbicidal activity. Infection by Leishmania takes place in the context of tissue repair. This article discusses cellular and molecular mechanisms involved in the intimate cooperation of neutrophils and macrophages in Leishmania infection.
Databáze: MEDLINE