Synthesis of β-amino acid derivatives via copper-catalyzed asymmetric 1,4-reduction of β-(acylamino)acrylates.
| Autor: | Wu Y; College of Material, Chemistry and Chemical Engineering and Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310036, China., Qi SB, Wu FF, Zhang XC, Li M, Wu J, Chan AS |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2011 Apr 01; Vol. 13 (7), pp. 1754-7. Date of Electronic Publication: 2011 Mar 02. |
| DOI: | 10.1021/ol200287z |
| Abstrakt: | A new set of reaction conditions has been established to facilitate the copper-catalyzed enantioselective 1,4-reduction of β-(acylamino)acrylates toward a selection of β-alkyl-β-amino acid derivatives in high yields and with uniformly high ee values (up to 99%) irrespective of the use of (E)- or (Z)-substrates. |
| Databáze: | MEDLINE |
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