Expression of a neural cell adhesion molecule serum fragment is depressed in autism.

Autor: Plioplys AV; Department of Pediatrics, University of Toronto., Hemmens SE, Regan CM
Jazyk: angličtina
Zdroj: The Journal of neuropsychiatry and clinical neurosciences [J Neuropsychiatry Clin Neurosci] 1990 Fall; Vol. 2 (4), pp. 413-7.
DOI: 10.1176/jnp.2.4.413
Abstrakt: The level of a neural cell adhesion molecule (NCAM) serum fragment in autism was determined by using an antiserum prepared with immunoaffinity purified mouse NCAM. Autistic patients (N = 16) had statistically significantly decreased serum NCAM levels compared with age-matched controls (p less than 0.0005). This observation could not be attributed to a medication-induced effect. Depressed serum NCAM levels in autism are distinct from schizophrenia, in which serum NCAM levels are elevated.
Databáze: MEDLINE