| Autor: |
Liew LP; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK., Bell SD |
| Jazyk: |
angličtina |
| Zdroj: |
The Biochemical journal [Biochem J] 2011 Jun 01; Vol. 436 (2), pp. 409-14. |
| DOI: |
10.1042/BJ20110084 |
| Abstrakt: |
The MCM (minichromosome maintenance) proteins of archaea are widely believed to be the replicative DNA helicase of these organisms. Most archaea possess a single MCM orthologue that forms homo-multimeric assemblies with a single hexamer believed to be the active form. In the present study we characterize the roles of highly conserved residues in the ATPase domain of the MCM of the hyperthermophilic archaeon Sulfolobus solfataricus. Our results identify a potential conduit for communicating DNA-binding information to the ATPase active site. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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