| Autor: |
Barber JM; Centre for Biodiscovery and School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand., Quek NC, Leahy DC, Miller JH, Bellows DS, Northcote PT |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2011 Apr 25; Vol. 74 (4), pp. 809-15. Date of Electronic Publication: 2011 Feb 25. |
| DOI: |
10.1021/np100868t |
| Abstrakt: |
Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E-K (5-11), four of which incorporate various sulfur functionalities. The structures of compounds 5-11 were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds 6-9 were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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