Antiproliferative activity of three methoxylated flavonoids isolated from Zeyheria montana Mart. (Bignoniaceae) leaves.

Autor: Seito LN; Universidade Estadual Paulista-UNESP, Institute of Biosciences, Department of Pharmacology Laboratory of Phytomedicines, Botucatu, SP, Brazil., Ruiz AL, Vendramini-Costa D, Tinti SV, de Carvalho JE, Bastos JK, Di Stasi LC
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2011 Oct; Vol. 25 (10), pp. 1447-50. Date of Electronic Publication: 2011 Feb 24.
DOI: 10.1002/ptr.3438
Abstrakt: The present study isolated three major active flavonoids, two flavones named 4',5,7-trimethoxy-luteolin (1) and 6-hydroxy-5,7-dimethoxyflavone (2) and the flavanone 5-hydroxy-6,7-dimethoxyflavanone (3) from Zeyheria montana dichloromethane leaf extract. Isolation and purification were conducted with the application of column chromatography and structures were assigned by spectral analysis. All compounds were evaluated for cytotoxic activities against human tumor cell lines UACC-62 (melanoma), MCF-7 (breast), NCI-ADR/RES (breast expressing phenotype multiple drug resistance), 786-0 (renal), NCI-H460 (lung, non-small cells), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) in vitro. All compounds were active in different degrees on several tumor cell lines and flavanone 3 showed cytotoxicity against almost all cell lines, particularly against human NCI-ADR/RES and K562 cell lines. In conclusion, three antiproliferative compounds were isolated for the first time from Zeyheria montana and its leaves were characterized as an important source of methoxylated flavones and flavanone as potential antitumor compounds.
(Copyright © 2011 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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