| Autor: |
Abdel-Rahman SM; Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA. srahman@cmh.edu, Chandorkar G, Akins RL, Bradley JS, Jacobs RF, Donovan J, Benziger DP |
| Jazyk: |
angličtina |
| Zdroj: |
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2011 Aug; Vol. 30 (8), pp. 712-4. |
| DOI: |
10.1097/INF.0b013e31820fc8e1 |
| Abstrakt: |
A pharmacokinetic analysis was performed for single intravenous doses of daptomycin 8 or 10 mg/kg in subjects aged 2 to 6 years. Proportional increases in maximum plasma concentration (68.4 μg/mL, 79.2 μg/mL) and area under the curve (429.1 μg · h/mL, 549.7 μg · h/mL) were observed for each dose cohort, respectively. Half-life, clearance, and distribution volume were similar between groups. Both doses were well tolerated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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