Controlled curing of adhesive complex coacervates with reversible periodate carbohydrate complexes.

Autor: Shao H; Department of Bioengineering, University of Utah, 20 S. 2030 East, Room 506C, Salt Lake City, Utah 84112., Weerasekare GM, Stewart RJ
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2011 Apr; Vol. 97 (1), pp. 46-51. Date of Electronic Publication: 2011 Feb 09.
DOI: 10.1002/jbm.a.33026
Abstrakt: Periodate oxidation of carbohydrates with vicinal hydroxyl groups and aromatic ortho-dihydroxyphenyl groups has been employed extensively to initiate crosslinking or conjugation reactions in adhesive biomaterials. Periodate forms stable tridentate complexes with carbohydrates containing three appropriately configured hydroxyls, such as 1,2-O-isopropylidene-a-D-glucofuranose, that are not appreciably oxidized relative to carbohydrates with vicinal hydroxyls and ortho-dihydroxyphenyl groups. In the presence of 1,2-O-Isopropylidene-a-D-glucofuranose the rate of periodate oxidation of dihydroxy containing compounds is controlled by the rates of association and dissociation of the periodate-carbohydrate complex. By varying the ratio of 1,2-O-isopropylidene-a-D-glucofuranose to periodate the curing rate of adhesive complex coacervates was varied over a wide range.
(Copyright © 2011 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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