| Autor: |
Weber K; AnaPath GmbH, Buchsweg 56, 4625 Oberbuchsiten, Switzerland. kweber@harlan.com, Razinger T, Hardisty JF, Mann P, Martel KC, Frische EA, Blumbach K, Hillen S, Song S, Anzai T, Chevalier HJ |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of toxicology [Int J Toxicol] 2011 Mar; Vol. 30 (2), pp. 162-73. Date of Electronic Publication: 2011 Feb 07. |
| DOI: |
10.1177/1091581810391818 |
| Abstrakt: |
The discussion on whether the Sprague Dawley (SD), the Fischer F344, or the Hannover Wistar rat is the most appropriate model for toxicity studies in rodents is ongoing. A substantial quantity of data on these strains concerning their source, diet, and housing conditions have been published. Generally, before starting a toxicology program in rodents, it should be taken into account that oncogenicity studies will be required for the majority of compounds successfully completing development. Survival, body weight development, incidence, type, time of onset of age-dependent lesions and neoplasms, as well as some special considerations of the rat model selected may be decisive. Therefore, an understanding of the historical background data is essential. These aspects demonstrate why the use of a specific rat model should be carefully considered at the beginning of the toxicology program. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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