| Autor: |
Arnoux R; Clinique chirurgicale du C.H.R., Bordeaux., Dufourcq J, Smeesters C, Lalanne J, Deminière C, Penin E, Clerc M, Poteaux L, Dartigues JF, Michel A, et. al. |
| Jazyk: |
francouzština |
| Zdroj: |
Chirurgie; memoires de l'Academie de chirurgie [Chirurgie] 1990; Vol. 116 (8-9), pp. 699-703. |
| Abstrakt: |
A preparation of cyclosporine A (CsA) in small liposomes (300 nm) was tested in a rat model of heterotopic cardiac allograft. At a daily dose of 1,5 mg/kg during 14 days, the graft survival rate was 30.4 +/- 2.8 days with a liposome-CsA solution versus 16 +/- 2.3 days with a Cremophore-CsA solution (p less than 0.01). Animals treated with the liposome-CsA preparation exhibited less weight loss than animals treated with cremophore-CsA solution (p less than 0.01). It is likely that the up-take of CsA by macrophages, when incapsulated into liposomes is dramatically enhanced; these cells have been pointed out at targets for IL2 inhibition by CsA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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