The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword.

Autor:	Hölzel M; Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.; current address: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands., Burger K; Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany., Mühl B; Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany., Orban M; Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany., Kellner M; Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany., Eick D; Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2010 May; Vol. 1 (1), pp. 43-47.
DOI:	10.18632/oncotarget.107
Abstrakt:	Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.
Databáze:	MEDLINE
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