[Tumor necrosis factor-alpha and interleukin-6 levels among patients suffering a bile duct injury during cholecystectomy].

Autor:	Miranda-Díaz AG; Departamento de Clínicas Quirúrgicas, Centro Universitario de Ciencias de la salud, Universidad de Guadalajara, Guadalajara, Jalisco, México. alexmiranda1@hotmail.com, Hermosillo-Sandoval JM, Huerta-Rosas G, López-Guillén GG, Cardona Muñoz EG, García-Iglesias T, Pacheco-Moisés F, Alatorre-Carranza Mdel P
Jazyk:	Spanish; Castilian
Zdroj:	Revista medica de Chile [Rev Med Chil] 2010 Oct; Vol. 138 (10), pp. 1259-63. Date of Electronic Publication: 2011 Jan 10.
DOI:	/S0034-98872010001100008
Abstrakt:	Background: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL6) to phagocyte toxic products Aim: To measure serum levels of TNF-α and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. Patients and Methods: Serum levels of TNF-α and IL-6 were measured prior to the bile-enteric derivation and after one year of follow up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls. Results: At baseline TNF-α levels in healthy subjects and patients with bile duct injury were 0 and 43.9 ± 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-á became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 ± 2.0 and 72.0 ± 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 ± 0.3 pg/mL among patients. Conclusions: TNF-α and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later.
Databáze:	MEDLINE
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