Peripheral somatosensation: a touch of genetics.

Autor: Reed-Geaghan EG; Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, United States., Maricich SM
Jazyk: angličtina
Zdroj: Current opinion in genetics & development [Curr Opin Genet Dev] 2011 Jun; Vol. 21 (3), pp. 240-8. Date of Electronic Publication: 2011 Jan 27.
DOI: 10.1016/j.gde.2010.12.009
Abstrakt: The somatosensory system processes information that organisms 'feel': joint position, muscle stretch, pain, pressure, temperature, and touch. The system is composed of a diverse array of peripheral nerve endings specialized to detect these sensory modalities. Several recent discoveries have shed light on the genetic pathways that control specification and differentiation of these neurons, how they accurately innervate their central and peripheral targets, and the molecules that enable them to detect mechanical stimuli. Here, we review the cadre of genes that control these processes, focusing on mechanosensitive neurons and support cells of the skin that mediate different aspects of the sense of touch.
(Copyright © 2011 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: