| Autor: |
Balaa MA; Good Samaritan Medical Groups, San Jose, CA 94124., Subramony C |
| Jazyk: |
angličtina |
| Zdroj: |
Eicosanoids [Eicosanoids] 1990; Vol. 3 (4), pp. 201-3. |
| Abstrakt: |
Exposure of the rat stomach to ethanol stimulates the generation of leukotrienes. Leukotrienes are potent mediators of tissue inflammation and injury. In this work we show that pretreatment with diethylcarbamazine, a lipoxygenase enzyme inhibitor, significantly decreases ethanol injury to the rat gastric mucosa. At a dose of 250 mg/kg the compound significantly reduced the ETOH-stimulated mucosal LTC4 generation by 40% and PGE2 generation by 79%. We conclude that diethylcarbamazine is an inhibitor of the cyclooxygenase and lipoxygenase enzymes in the gastric mucosa. That inhibition of leukotriene synthesis decreases the extent of ethanol-stimulated suggests that leukotrienes play a key role in mediating ethanol-injury to that tissue. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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