[Adrenal androgen participation in the polycystic ovary syndrome].
| Autor: | Gil Junior AB; Médico do Hospital Universitário Júlio Müller da Universidade Federal de Mato Grosso – UFMT Cuiabá (MT), Brasil., Rezende AP, do Carmo AV, Duarte EI, de Medeiros MM, de Medeiros SF |
|---|---|
| Jazyk: | portugalština |
| Zdroj: | Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2010 Nov; Vol. 32 (11), pp. 541-8. |
| DOI: | 10.1590/s0100-72032010001100005 |
| Abstrakt: | Purpose: to reassess the adrenal function of patients with PCOS after the introduction of the Rotterdam's criteria. Methods: descriptive and cross-sectional study including 53 patients 26 ± 5.1 years old. Glucose, glycosylated hemoglobin, lipids, estradiol, progesterone, 17-OHP4, DHEAS, FSH, LH, TSH, PRL, androstenedione, free thyroxine, insulin, total testosterone, SHBG, and free androgen index were measured. Insulin resistance was considered to be present with a homeostatic model assessment index >2.8. The adrenal response to cortrosyn was assessed by the hormonal rise observed at 60 minutes, and by the area under the response curve. Results: biochemical hyperandrogenism was found in 43 of 53 eligible patients (81.1%). Thirty-three women had adrenal hyperandrogenism (62.2%). The weight of these 33 women, aging 25.1 ± 5.0 years, was 74.9 ± 14.9 kg, BMI was 28.8 ± 6.0 and the waist/hip ratio was 0.8 ± 0.1. DHEAS was >6.7 nmol/L in 13 (39.4%) and androstenendione was >8.7 nmol/L in 31 (93.9%). The increments in 17-OHP4, cortisol, A, and progesterone were 163%, 153%, 32%, and 79%, respectively. The homeostatic insulin resistance model was >2.8 in 14 (42.4%). Insulin and estradiol were not correlated with cortisol or androgens. Conclusions: the use of multiple endocrine parameters showed a high prevalence of biochemical hyperandrogenism in patients with PCOS. Two thirds of the patients had adrenal hyperandrogenism, and estradiol and insulin did not influence adrenal secretion. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|