| Autor: |
Timoshin AA, Pisarenko OI, Tskitishvili OV, Serebriakova LI, Studneva IM, Drobotova DIu, Ruuge EK, Vanin AF |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2010 Nov-Dec; Vol. 55 (6), pp. 1099-107. |
| Abstrakt: |
The injection of dinitrosyliron iron complexes with glutathione at the onset of 40-min rat regional myocardial ischemia was shown to exert a clear cardioprotective action by decreasing the infarct size and suppressing the cardiac rhythm disturbance. After the introduction of the preparation, its effective accumulation with protein thiol-containing ligands in the myocardial tissue was registered be the EPR method. It was also found that, as a result of postischemic reperfusion, the rate of the decrease in the content of these complexes in the ischemic area increases, which demonstrates the effective scavenging of short-lived reactive oxygen species by molecules of dinitrosyl iron complexes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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