[Expression of tissue inhibitor of metalloproteinase-2 in nasopharyngeal carcinoma].

Autor:	Yao L; Department of Otolaryngology, Beijing University Shenzhen Hospital,Shenzhen, 518036, China. yllp20@tom.com, Liu P, Lu X, Liu F
Jazyk:	čínština
Zdroj:	Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2010 Sep; Vol. 24 (18), pp. 831-3.
Abstrakt:	Objective: To study the expression of tissue inhibitor of matrix metalloproteinase 2 (TIMP2)in the nasopharyngeal carcinoma and to evaluate the relationships between the expression of TIMP2 and biological behavior of NPC. Method: The expression of TIMP2 was observed by immunohistochemical technique in 50 cases with nasopharyngeal carcinoma and 15 cases of Inflammation nasopharyngeal tissues. Result: The positive rates of TIMP2 are significantly higher in NPC than in Inflammation tissues (P < 0.05). The expression of TIMP2 increase significantly with lymph node metastasis (P < 0.01), but had no relevant to the rise clinical invasion stage (P > 0.05). Conclusion: The results indicate that TIMP2 may play a critical role in assisting carcinoma cell to degrade basement membrane to invade surrounding tissues and to form metastatic colonies in lymph node. Especially the unbalance in MMP2/TIMP2 has probably a prognostic value in nasopharyngeal carcinoma.
Databáze:	MEDLINE
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