| Autor: |
Corrah TW; Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom., Goonetilleke N, Kopycinski J, Deeks SG, Cohen MS, Borrow P, McMichael A, Brackenridge S |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 2011 Apr; Vol. 85 (7), pp. 3367-74. Date of Electronic Publication: 2011 Jan 19. |
| DOI: |
10.1128/JVI.02276-10 |
| Abstrakt: |
Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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