| Autor: |
Viglinskaya AO; V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. aviglinskaya@gmail.com, Bastrygin DV, Kolyvanov GB, Litvin AA, Zherdev VP, Mozhaeva TY |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Sep; Vol. 149 (3), pp. 318-9. |
| DOI: |
10.1007/s10517-010-0936-x |
| Abstrakt: |
Comparative analysis of pharmacokinetic parameters of afobazole and its main metabolite M-11 after single intraperitoneal injections of their solutions (25 mg/kg) to rats showed much more intense penetration of M-11 compared to afobazole into rat tissues and organs, judging from the area under the pharmacokinetic curve (AUC) and maximum concentrations (C(max)). The half-life periods (T(l/2e)l) of afobazole and M-11 were similar. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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