The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.
| Autor: | Eccles KS; Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland., Deasy RE, Fábián L, Maguire AR, Lawrence SE |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of organic chemistry [J Org Chem] 2011 Feb 18; Vol. 76 (4), pp. 1159-62. Date of Electronic Publication: 2011 Jan 18. |
| DOI: | 10.1021/jo102148p |
| Abstrakt: | Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals. (© 2011 American Chemical Society) |
| Databáze: | MEDLINE |
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