Association between environmental quality, stress and APOE gene variation in fibromyalgia susceptibility determination.
| Autor: | Becker RM; Physical Therapy Course at Universidade Feevale, Novo Hamburgo, Brazil., da Silva VK, Machado Fda S, dos Santos AF, Meireles DC, Mergener M, dos Santos GA, de Andrade FM |
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| Jazyk: | English; Portuguese |
| Zdroj: | Revista brasileira de reumatologia [Rev Bras Reumatol] 2010 Nov-Dec; Vol. 50 (6), pp. 617-24. |
| Abstrakt: | Introduction: Fibromyalgia is a multifactorial disease, of which etiology is based on interaction between genetic susceptibility and environment. However, few studies attempted to identify the risk factors. Objective: To investigate the genetic influence and its interaction with environmental quality and stress, as possible risk factors for fibromyalgia development. Patients and Methods: This cross-sectional study investigated two groups of women, of which 47 had a clinical diagnosis of fibromyalgia, and 41 women comprising thre control group, all from the town of Novo Hamburgo, RS. The apolipoprotein E (APOE) gene polymorphism was analyzed in DNA extracted from total blood, in both samples. Environmental factors were studied through Lipp's Inventory of Stress Symptoms for Adults and by applying the WHOQOL-100 domain V. Results: Among the patients, more women had high stress levels when compared to the control sample (P < 0.001); moreover, the average scores of the WHOQOL-100 domain V, which analyze environment quality, were lower in this group (P < 0.001). APOE genotypic and allelic frequencies were similar between the two groups. Multivariate analysis showed that low WHOQOL-100 scores increase the chance of disease development by 57.7 times (P < 0.001), and that high stress levels were related with the disease (OR = 197.2; P < 0.001). This approach pointed out an interaction between stress and presence of E*2 allele (P = 0.028). Fibromyalgia was much more frequent in patients with high stress levels that were E*2 non-carriers (estimated OR = 265.1), when compared to patients with the same stress level, but E*2 carriers (estimated OR = 1.06). Conclusion: E*2 allele presence could have a protective action regarding the association between fibromyalgia and stress. |
| Databáze: | MEDLINE |
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