Thrombomodulin Biology and potential cardiovascular applications.
| Autor: | Dittman WA; Department of Medicine, Durham VAMC USA; Duke University School of Medicine, Durham, NC 27705, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Trends in cardiovascular medicine [Trends Cardiovasc Med] 1991 Dec; Vol. 1 (8), pp. 331-6. |
| DOI: | 10.1016/1050-1738(91)90070-U |
| Abstrakt: | Thrombomodulin on endothelial surfaces is the major cofactor for the activation of the anticoagulant protein C by thrombin. Recent studies of the structure and regulation of thrombomodulin provide important clues as to its mechanism of action. These studies should enable the rational use of thrombomodulin as a therapeutic agent to inhibit coagulation either by infusion of thrombomodulin or its derivatives, or by pharmacologic alteration of cellular levels. (Copyright © 1991. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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