A retrospective study of the relation between vaccination and occurrence of seizures in Dravet syndrome.

Autor: Tro-Baumann B; Department of Neuropediatrics, BHZ Vogtareuth, Epilepsy Center, Vogtareuth, Germany., von Spiczak S, Lotte J, Bast T, Haberlandt E, Sassen R, Freund A, Leiz S, Stephani U, Boor R, Holthausen H, Helbig I, Kluger G
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2011 Jan; Vol. 52 (1), pp. 175-8. Date of Electronic Publication: 2011 Jan 04.
DOI: 10.1111/j.1528-1167.2010.02885.x
Abstrakt: Dravet syndrome is a severe epileptic encephalopathy starting in the first year of life. Mutations in SCN1A can be identified in the majority of patients, and epileptic seizures in the setting of fever are a clinical hallmark. Fever is also commonly seen after vaccinations and provocation of epileptic seizures by vaccinations in patients with Dravet syndrome has been reported, but not systematically assessed. In a retrospective evaluation of 70 patients with Dravet syndrome and SCN1A mutations, seizures following vaccinations were reported in 27%. In 58% of these patients vaccination-related seizures represented the first clinical manifestation. The majority of seizures occurred after DPT vaccinations and within 72 h after vaccination. Two-thirds of events occurred in the context of fever. Our findings highlight seizures after vaccinations as a common feature in Dravet syndrome and emphasize the need for preventive measures for seizures triggered by vaccination or fever in these children.
(Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.)
Databáze: MEDLINE
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