Conclusions of the French Food Safety Agency on the toxicity of bisphenol A.

Autor: Arnich N; Agence Française de Sécurité Sanitaire des Aliments, Maisons-Alfort, France. nathalie.arnich@anses.fr, Canivenc-Lavier MC, Kolf-Clauw M, Coffigny H, Cravedi JP, Grob K, Macherey AC, Masset D, Maximilien R, Narbonne JF, Nesslany F, Stadler J, Tulliez J
Jazyk: angličtina
Zdroj: International journal of hygiene and environmental health [Int J Hyg Environ Health] 2011 Jun; Vol. 214 (3), pp. 271-5. Date of Electronic Publication: 2011 Jan 07.
DOI: 10.1016/j.ijheh.2010.12.002
Abstrakt: Since more than 10 years, risk assessment of bisphenol A (BPA) is debated at the international level. In 2008, the U.S. National Toxicology Program (NTP) expressed some concern for adverse effects, at current level of exposure to BPA, on developmental toxicity. In this context, the French Food Safety Agency (AFSSA) decided to review the toxicity data on BPA with a special focus on this endpoint at doses below 5mg/kg bw/day (the no observed adverse effect level set by different regulatory bodies). This paper summarizes the conclusions of a collective assessment conducted by an expert Working Group from AFSSA. Studies were classified into 3 groups: (i) finding no toxicity, (ii) reporting results not considered to be of concern and (iii) indicating warning signals. The term "warning signal" means that no formal conclusion can be drawn regarding the establishment of a health based guidance value but the study raises some questions about the toxicity of BPA at low doses. It was concluded that studies are needed to ascertain the significance for human health of these warning signals and to be able to propose new methodologies for assessing the risks associated with low doses of BPA and more generally of endocrine disruptors.
(Copyright © 2011 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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