| Autor: |
Cheung DL; University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia., Hart PH, Vitti GF, Whitty GA, Hamilton JA |
| Jazyk: |
angličtina |
| Zdroj: |
Immunology [Immunology] 1990 Sep; Vol. 71 (1), pp. 70-5. |
| Abstrakt: |
Stimulated human monocytes/macrophages are a source of interleukin-6 (IL-6), which is a likely mediator involved in immune and inflammatory reactions. The means to control production of IL-6 by these cells could therefore have therapeutic applications. We report here, for lipopolysaccharide (LPS)-stimulated human monocytes in vitro, that the lymphokine, interferon-gamma (IFN-gamma) (100 U/ml), enhanced the level of IL-6 activity, whereas another lymphokine, interleukin-4 (IL-4) (greater than or equal to 0.1 U/ml; greater than or equal to 1.2 x 10(-11) M), suppressed it. The effects of the two lymphokines were manifested at the level of mRNA. The action of the IL-4 was similar to that of the glucocorticoid, dexamethasone, but observed at a lower molar concentration. Such regulation of monocyte IL-6 activity is similar to that found previously for interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-alpha) synthesis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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