Helicobacter pylori eradication lowers serum asymmetric dimethylarginine levels.
| Autor: | Aydemir S; Department of Gastroenterology, Faculty of Medicine, Zonguldak Karaelmas University, 67800 Zonguldak, Turkey. selimaydemir@hotmail.com, Eren H, Tekin IO, Harmandar FA, Demircan N, Cabuk M |
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| Jazyk: | angličtina |
| Zdroj: | Mediators of inflammation [Mediators Inflamm] 2010; Vol. 2010, pp. 685903. Date of Electronic Publication: 2010 Dec 13. |
| DOI: | 10.1155/2010/685903 |
| Abstrakt: | Introduction: Microbial pathogens, one of them is Helicobacter pylori (H. pylori), have frequently been implicated in the atherogenesis. Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS) and plays a pivotal role in the regulation of vascular tone. Asymmetric dimethylarginine (ADMA) is the most potent endogenous NOS inhibitor. Elevated levels of ADMA have been reported in many circumstances associated with a high cardiovascular risk. The aim of the present study was to investigate whether the eradication of H. pylori infection affects serum ADMA levels. Materials and Methods: Forty-two H. pylori-positive patients were enrolled in the study. Triple therapy for 14 days were given to all patients. Serum ADMA levels were measured at baseline and 2 months after therapy. Results: Eradication was achieved in 34 (81%) patients. The mean serum ADMA levels before and after therapy were 1, 77 ± 0, 30 and 1, 67 ± 0, 29 ng/mL in the group with H. pylori eradicated and 1, 63 ± 0, 28 and 1, 56 ± 0, 32 ng/mL in the noneradicated, respectively. We detected statistically significant decreased serum ADMA levels after therapy in H. pylori eradicated group. Conclusion: These findings have indicated that eradication of H. pylori infection may decrease the risk of atherosclerosis and cardiovascular events. |
| Databáze: | MEDLINE |
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