Isolation and characterization of a process impurity in tizanidine hydrochloride.

Autor: Vijayakumar EK; Mylan India Pvt. Ltd., Plot 1A/2, M.I.D.C. Industrial Estate, Taloja - 410 208, India., Gore VG, Mahajan A, Kumar M
Jazyk: angličtina
Zdroj: Indian journal of pharmaceutical sciences [Indian J Pharm Sci] 2010 May; Vol. 72 (3), pp. 360-2.
DOI: 10.4103/0250-474X.70484
Abstrakt: A new process impurity was detected during the HPLC analysis of Tizanidine hydrochloride (I) batches. The impurity (II) was isolated by preparative HPLC and characterized by NMR and Mass spectral analysis as 5-S-ethyl-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride.
Databáze: MEDLINE