| Autor: |
Sapkal NP; Gurunanak College of Pharmacy, Near Dixit Nagar, Nari, Nagpur-440 026, India., Kilor VA, Shewale BD, Bhusari KP, Daud AS |
| Jazyk: |
angličtina |
| Zdroj: |
Indian journal of pharmaceutical sciences [Indian J Pharm Sci] 2010 May; Vol. 72 (3), pp. 318-23. |
| DOI: |
10.4103/0250-474X.70477 |
| Abstrakt: |
Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with β-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with β-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with β-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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