| Autor: |
Marcucci F; Department of Medical and Surgical Specialty and Public Health, Institute of Pediatrics, Perugia, Italy., Sensi LG, Abate P, Allocca G, Ugolini E, Di Cara G, Incorvaia C |
| Jazyk: |
angličtina |
| Zdroj: |
Inflammation & allergy drug targets [Inflamm Allergy Drug Targets] 2011 Feb; Vol. 10 (1), pp. 32-8. |
| DOI: |
10.2174/187152811794352033 |
| Abstrakt: |
The non-sedating third generation antihistamine levocetirizine has ample evidence of efficacy in allergic rhinitis. In vitro studies suggested that levocetirizine has anti-inflammatory properties not simply related to the antihistamine activity but also to regulation of eosinophils. We performed a double-blind placebo-controlled study in 40 children allergic to house dust mites with persistent rhinitis with the primary aim to evaluate the anti-inflammatory efficacy of levocetirizine measuring eosinophil-related parameters and exhaled nitric oxide (eNO). After one month of treatment, a significant improvement in nasal symptom-medication scores was observed in actively but not in placebo treated patients. After 3 months of treatment, a significant effect was detected on eosinophilic cationic protein (ECP) in nasal mucosa and on nasal eNO in active treated patients. This suggests that during treatment of mite-allergic children with levocetirizine the early improvement in nasal symptoms is due to the antihistamine activity, while more time is needed to achieve an effect on allergic inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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