| Autor: |
Cochrane LE; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College, Dublin, Ireland., Tansey KE, Gill M, Gallagher L, Anney RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Autism research : official journal of the International Society for Autism Research [Autism Res] 2010 Dec; Vol. 3 (6), pp. 342-4. Date of Electronic Publication: 2010 Dec 03. |
| DOI: |
10.1002/aur.157 |
| Abstrakt: |
Autism is a neurodevelopmental disorder characterized by impairments in three core areas--language, social interaction and restricted/repetitive behaviours. It is generally accepted that genetics plays a large role in the aetiology of autism, but the exact mechanism is still unknown. We recently published evidence of an association between autism and the ITGA4 gene [Conroy et al., 2008]. Two genomic regions have shown evidence of linkage to autism in multiple studies--2q31-q33 and 17q21-q22. Both of these regions harbour multiple integrin subunit genes. We tested markers in ITGA3, ITGA6, ITGAV and ITGB3 for association with autism in the Irish autism sample. No markers in ITGA3, ITGA6, ITGAV and ITGB3 were found to be associated with autism. Three 3-marker haplotypes in ITGAV, ITGA3 and ITGA6 were found to be nominally associated (0.01 < P < 0.05) and to have unremarkable findings. Our data indicates that in the Irish autism sample the integrin genes tested here do not play an important role in the aetiology of autism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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