| Autor: |
Zheng QY; The Jackson Laboratory, Bar Harbor, Maine 04609, USA., Harris BS, Ward-Bailey PF, Yu H, Bronson RT, Davisson MT, Johnson KR |
| Jazyk: |
angličtina |
| Zdroj: |
Academic journal of Xian Jiaotong University : AJXJTU = Xi'an jiao tong da xue xue bao (Yi wen ban) [Acad J Xian Jiaotong Univ] 2004 Jun; Vol. 25 (3), pp. 209-212. |
| Abstrakt: |
OBJECTIVE: to map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. METHODS: genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. RESULTS: 1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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