Outcomes following renal transplantation after multiorgan retrieval versus kidney-only retrieval in donation after cardiac death donors.

Autor: Goldsmith PJ; Department of Organ Transplantation, St James’s University Hospital, Leeds, United Kingdom. Goldsmithpaul@hotmail.com, Ridgway DM, Pine JK, Speak G, Newstead C, Lewington AJ, Menon KV, Ahmad N, Attia M
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2010 Dec; Vol. 42 (10), pp. 3963-5.
DOI: 10.1016/j.transproceed.2010.09.145
Abstrakt: With the increase of donation after cardiac death (DCD) now including procurements for not only kidney but also liver, pancreas, and lung transplantations, we analyze whether multiorgan DCD retrievals have a negative impact on immediate and short-term renal transplant outcomes due to increased length of time of explantation of the kidney from the donor and the associated risks of re-warming. We performed a retrospective study of all DCD donors from 2002 to 2009 at a single unit. Immediate and short-term outcomes between kidney-only versus multiorgan retrieval were compared. Cold ischaemia was significant between the two groups (P = .04), but all other variables were nonsignificant. The results show that immediate graft function, rates of acute rejection and graft/recipient survival are comparable when DCD allografts are procured from both multiorgan and kidney-only donors. The comparable outcomes from kidney-only and multiorgan donations in this study may be due to by the highly selective use of donors for multiorgan DCD donation. This selectivity may explain the "better" quality of kidney for these cases in which patients were able to tolerate potentially injurious rewarming.
(Copyright © 2010 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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